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Others endured severe gastrointestinal symptoms, including vomiting, diarrhea, cramping and abdominal pain

& Knappstein, K

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In addition to these desirable effects, RK stimulating IGF-1 can also inhibit inflammation via stimulation of IL-10 production, reducing the overall visible redness seen in KP [15]

Patients on this protocol who also use metabolic support agents like Metformin should note that both agents activate AMPK, and physician oversight is warranted to avoid compounding effects on blood glucose that could theoretically cause hypoglycemia in susceptible individuals, though this has not been reported clinically with MOTS-c at standard doses