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The sustained nature of the GLP-1 increase suggests the possibility that metformin may in part provide cardio-metabolic benefit, even in a non-diabetic population and beyond reducing the risk of developing T2DM, by increasing exposure of treated individuals to GLP-1 in the longer term

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Among the lipid metabolism-related genes, Scd1 , Fabp4 , and Mogat2 were significantly upregulated in the WD-fed MC4R-KO mice

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Clinicians should counsel patients that full therapeutic effects on HbA1c and weight may not be apparent until 12 to 16 weeks after initiation

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