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Retatrutide Advantages Highest weight loss ever reported in an obesity drug trial Third receptor adds energy expenditure and fat oxidation Weight loss curve not yet plateaued at 48 weeks Stronger liver fat reduction potential via glucagon pathway 100% of highest-dose participants lost at least 5% body weight Tirzepatide Advantages FDA approved and commercially available (Mounjaro, Zepbound) Large Phase 3 dataset with 10,000+ participants across programs No dose-dependent heart rate increase observed Longer real-world data and post-marketing surveillance Multiple completed trials across obesity and diabetes indications Key Takeaways Retatrutides Phase 2 data shows a small numerical weight loss advantage over tirzepatides Phase 3 data (24.2% vs 22.5%), but the comparison is indirect and the trial designs are not equivalent