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doi:10.1038/s41598-026-37537-4 CrossRef Abbreviation AGEs Advanced Glycation End Products AP-1 Activator Protein-1 CAT Catalase COX-2 Cyclooxygenase-2 ECM Extracellular Matrix FGF Fibroblast Growth Factor GSH Reduced Glutathione HPLC High-Performance Liquid Chromatography IL-1 Interleukin-1 Beta IL-6 Interleukin-6 iNOS Inducible Nitric Oxide Synthase Keap1 Kelch-like ECH -associated Protein 1 LC-MS Liquid ChromatographyMass Spectrometry MDA Malondialdehyde MMPs Matrix Metalloproteinases NADPH Nicotinamide Adenine Dinucleotide Phosphate NF-B Nuclear Factor Kappa B NMR Nuclear Magnetic Resonance Nrf2 Nuclear Factor Erythroid 2Related Factor 2 PDGF Platelet-Derived Growth Factor ROS Reactive Oxygen Species SOD Superoxide Dismutase STZ Streptozotocin TGF- Transforming Growth Factor Beta TNF- Tumour Necrosis Factor Alpha VEGF Vascular Endothelial Growth Factor Received on: 02-03-2026 Accepted on: 25-03-2026 Reviewed by: Dr

Kan, and J.Y

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Tirzepatide is a dual GLP-1/GIP receptor agonist that has been approved by the FDA and is currently marketed in various dosage strengths and forms as Mounjaro and Zepbound