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AOD-9604 minimizes systemic effects by not interacting with growth hormone receptors, in contrast to human growth hormone, from which it is produced

While clinical development for obesity was discontinued in 2007 after a Phase IIb trial failed to achieve its primary endpoint, the peptide remains a valuable research tool for investigating adipose tissue biology, lipolytic pathways, and receptor-independent signaling mechanisms

No published human clinical trial exists

Tirzepatide Tirzepatide is a once weekly GIP (Glucose-depenent Insulinotropic Polypeptide) receptor and GLP-1 (glucagon-like peptide-1) receptor agonist, representing a new class of medicines studied for the treatment of obesity

This is a valid concern with GLP-1 **weight loss peptides** approximately 25-40% of weight lost with semaglutide comes from lean mass