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Moreover, it was suggested from inhibition data that 23 (HA08) acting through a competitive mechanism and Ang IV may occupy the same binding site and operate by the same mode of action

In addition, 58.3% of the Pycnogenol patients were able to maintain blood pressure control with half of their hypotensive medication, which was significant compared to only 20% of subjects in the placebo group

These studies mark the first administration of a drug candidate to human subjects and provide the initial clinical evidence needed to guide subsequent phases of development

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The last clinical review was completed on 15/02/2026, with the next review scheduled for 15/02/2027.