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The principal neurological function regulated by GLP-1RA could be summarized as follows ( Figure 2 ): (1) GLP-1RA liraglutide and exendin-4 effectively inhibited neuronal apoptosis (15), and ultimately improved early brain injury by suppressing NLRP3 inflammasome and inflammatory reaction in microglia (3436)

Bioenergetic approaches for neuroprotection in Parkinson's disease

Jul - Aug 2019;13(4):2463-2468

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But when combined with GLP-1 and GIP activation, the hyperglycemic effects are neutralized , while the lipid-lowering benefits remain