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Sec is a highly reactive amino acid that gives unique properties to selenoproteins [12]
10.1038/s41593-020-00794-1 42 Familiescn2a Foundation (2023)
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Furthermore, therapeutic agents targeting mitochondrial enzymes such as SHMT2, PDH, and CPT1A remain largely in preclinical or early-phase clinical development, with limited data available on optimal delivery strategies, pharmacokinetics, and safety profiles [24]
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