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However, the relevance of these findings and hence of the role of lysosomal cathepsin D in in vivo APAP-mediated acute liver failure is uncertain given the minor role of CYP3A4 in APAP metabolism (see above)

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For those who havent followed the hype, GLP-1 agonists are synthetic drugs that mimic a natural hormone which signals the brain to stop eating, helps release insulin, and slows digestion