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In research, Dihexa has been studied in oral formulations and subcutaneous injections

144,145,146,147,148,149,150,151,152 Once in the intestinal lumen, UA can either be directly excreted or metabolized by the gut microbiota

An 1290 HPLC system (Agilent Technologies, Palo Alto, USA) and a 6460 triple-quadrupole mass spectrometer (Agilent Technologies, Palo Alto, USA) were used