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From a pharmacological standpoint, several considerations are relevant: Gastrointestinal effects : Retatrutide, like other GLP-1-based therapies, commonly causes nausea, vomiting, diarrhoea, and reduced appetite

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50,51 GIP infusion reduced aortic plaque formation, intra-plaque macrophage accumulation, and foam cell formation in diabetic mice, while its overexpression stabilizes the atherosclerotic plaque in non-diabetic animals

[7] Cagrilintides cardiometabolic story is, at the standalone level, less developed

See the AAAaAI review, a related PubMed case series and an FDA pharmacovigilance memo for more detail