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Sahakian, L

Upon release, Nrf2 translocates to the nucleus where it can bind to the antioxidant response element (ARE) located in the promoter region of genes coding for antioxidant enzymes and scavengers

Thats where glutathione steps in - it sits inside the mitochondria like a live-in cleaner, mopping up reactive oxygen before it can cause chaos

Given that we cant survive without these other substances, the fact that we have so much glutathione around tells us that it is just as important

However, the practice of using glutathione for PD was not widespread, because it had to be administered directly into the veins (IV), necessitating clinic visits and medical staff inserting needles for proper administration