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Estradiol: Timing, Route, and the Window of Opportunity The Women's Health Initiative (WHI), published in 2002 and 2004, cast a long shadow over hormone therapy that has proven, on closer examination, to be partly a shadow of methodological limitation rather than true hazard

In the same thirty-three years, exactly one Phase I clinical trial in humans was registered

This time came and went, and we got back in line with Kaiser patients hoping that the cost of surgery would still be covered by Kaiser before the rules changed again, and that Will would indeed have the surgery before leaving home for college

References Anonymous, 1985

Although, none of the above methods is the perfect and reliable technique to assess glutamatergic pathways in patients with depression