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3.6.1 Defining ROPE and clinical significance While frequentist meta-analyses are widely applied within the PCOS evidence-based framework, their conclusions often fail to directly address threshold-based clinical questions

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To the extent that both compounds have been used in clinical settings, the available data indicate vastly different dosage recommendations, frequency of use, and routes of administration: MK-677 is taken as oral capsules, usually once daily, thanks to its relatively long half-life

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