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While tirzepatide does not directly target these pathways, the metabolic improvements and weight reduction it facilitates may indirectly support healthier reproductive hormone profiles

However, Semaglutide is most effective when coupled with routine exercise and a healthy diet

Stopping GLP-1 medications typically leads to weight regain, with most people regaining 50-70% of lost weight within 12 months as appetite and metabolic adaptations return

Individual responses vary based on baseline BMI, adherence to lifestyle changes, and other factors