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The peptide activates tissue remodeling through stimulation of decorin, which organizes collagen fibril architecture, and through suppression of transforming growth factor-beta (TGF-) signaling, reducing fibrotic scar formation [3]

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On the other hand, the NOS inhibitor was reported to inhibit the beneficial effects of nicorandil 48,49,50 without altering the antinociceptive effect of nicorandil/morphine combination in tail flick and formalin test in liver fibrotic rats 48

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