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Considering these changes in T2DM and the critical role of GLP-1 in glucose homeostasis, strategies for managing T2DM based on this hormone include addressing the differentiation of L-cells, increasing the endogenous production and secretion of GLP-1 through stimulants, extending the half-life of GLP-1 by inhibiting its degrading enzyme and targeting GLP-1R using its agonists

Once-Monthly Maridebart Cafraglutide for the Treatment of Obesity A Phase 2 Trial

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(iii) Discontinuation and washout: For semaglutide, product labeling advises discontinuation at least 2 months before a planned pregnancy (153)