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Drug interactions Berberine may inhibit several cytochrome P450 enzymes (including CYP3A4, CYP2D6, and CYP2C9) and P-glycoprotein, potentially affecting the metabolism of numerous medications including statins, anticoagulants, antihypertensives, and immunosuppressants

They can contribute to muscle loss if nutrition and strength training are ignored

It promotes tissue repair through enhanced fibroblast activity and new blood vessel formation

Although the results point to a possible protective effect on bone health, researchers say additional prospective studies are needed to confirm the association