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Tendinopathy causes a decrease in collagen in the injured tendon, but it actually causes an increase in proteoglycans and GAGs, such as chondroitin sulfate and hyaluronan.[7,8,13,18,40] Gluscosamine sulfate and chondroitin sulfate might help build proteoglycans, but since the levels of GAGs and proteoglycans are already abnormally high in tendinopathy, you wouldn't expect oral supplementation of glucosamine and chondroitin to help

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These cells sit in the connective tissue beneath the skin, loaded with granules containing histamine, heparin, and various enzymes

They may also undercount side effects or relapse after discontinuation