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These studies have only examined one form of reduced folate, folinic acid, and have only examined treatment response in limited studies

Cellular damage caused by oxidative stress can release autoantigens and activate an autoimmune response, contributing to melanocyte destruction.4,28,67,68 Former studies have shown elevated levels of oxidative stress biomarkers, such as malondialdehyde (MDA), and decreased antioxidants, such as superoxide dismutase (SOD) and catalase, in both affected skin and blood of patients

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