A decreased renal insulin clearance might lead to higher insulin levels, in the organ or systemically, favoring IR
Figure 4C showed appendectomy did not increase risk of CRC(OR:1.005, 95%CI:0.992-1.018, P=0.459)
Lancet 387(10019):679690 Newsome PN, Buchholtz K, Cusi K, Linder M, Okanoue T, Ratziu V, Sanyal AJ, Sejling A-S, Harrison SA (2021) A placebo-controlled trial of subcutaneous semaglutide in nonalcoholic steatohepatitis
Because B12 injections deliver B12 straight into your muscle and bloodstream, they skip the slow digestive route that oral pills rely on, so you notice the difference far sooner than you'd expect
I noticed floaties any time I took it. She rated it a 3 out of 5 in that category