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The body needs time to adapt to each dose level, and GI side effects (nausea, decreased appetite, occasional diarrhea) tend to peak within the first 1-2 weeks of a new dose and then diminish

Another aspect of the invention is that sequential administration of low doses of a PDE-5 inhibitor and PT-141 for treatment of sexual dysfunction provides a therapeutic effect equal or superior to administration of a high dose of any one single agent without the side effects attendant to administration of a high dose of any one single agent

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Although the Central Nervous System (CNS) has long been considered an immune-privileged site due to its protective barriers, it is not fully isolated from the peripheral immune system and can respond to signals of injury or dysfunction from peripheral organs [10]

Individual experience only