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Step 4: Preparation of compound of formula-13 The reaction mixture obtained in step 3 was slowly added to a mixture of ethanol (850 ml), DIPEA (64 ml) and 2-(2-(2-aminoethoxy)ethoxy)acetic acid compound of formula- 10 (50 gm) at 25-30C and stirred the obtained reaction mixture for 45 min at the same temperature

67 In line with a role of ATII in endothelial dysfunction and hypertension, numerous studies have now demonstrated that the therapy with angiotensin-converting enzyme inhibitors and AT-1 receptor blockers is associated with an improvements in endothelial responsiveness 68, 69, 70, 71, 72 (the existence of negative reports also needs to be acknowledged)

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126 Regarding the latter, overlying epidermal hyperplasia and a storiform arrangement of spindle cells amidst sclerotic stroma typical of a benign fibrohistiocytic neoplasm are characteristic