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However, hypersensitivity or allergic reactions to current medications, as well as defects in certain BBSome genes that disrupt NPY2 receptor trafficking to primary cilia, may limit the effectiveness of these therapies in specific BBS cases (47)

Treatment with HDAC inhibitors in R6/2 a HD mouse model showed improvement in rotarod performance, which indicates improvement in motor impairment (Ellrichmann et al., 2017)