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Large outcome trials like LEADER (liraglutide), SUSTAIN-6 (semaglutide), and REWIND (dulaglutide) have shown clear cardiovascular benefits despite the heart rate increase

Furthermore, recent finding reported that GLP-1 RAs significantly reduced C-reactive protein (CRP) levels in obese IBD patients, alongside a nearly statistically significant reduction in fecal calprotectin (100)

Researchers emphasised that GLP-1 receptor agonist therapy remains essential for patients who are ineligible for surgery or seeking non-surgical intervention

A., Tailor, V., Bhide, A

Persistent vomiting or signs of dehydration require prompt medical review