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However the global prevalence of MocoD is likely to be underestimated as a result of a failure to diagnose or to report (28, 30, 31)

Oct 2006;136(10):2506-2511

But Hashimoto's patients often deal with fatigue , joint pain, and exercise intolerance that make intense training difficult

3.1 A schematic diagram showing the enteral routes of drug administration (oral, sublingual and rectal) and their relative susceptibility to first-pass elimination, influencing the absorption and bioavailability of a drug