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To gain a deeper understanding of the cellular mechanisms underlying WD, a reanalysis of the GSE1073236 dataset was conducted and validated by comparative analyses in a cell culture model of HepG2 and HepG2 ATP7B knockout (ATP7B-KO) cells, as well as in primary hepatocytes from WD patients and controls

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Glutatin oxidado (GSSG): que se recicla de nuevo a GSH a travs de enzimas

In order to investigate the participation of GSH in cystine-induced cell signaling, we investigated the effects of cystine starvation on GSH homeostasis

However, recent studies showed that NAC could also reverse lipid ROS levels and act as an inhibitor against ferroptosis [39, 40]