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A further increase in the level of oxidative stress could ultimately trigger a cytotoxic response originating in the mitochondria and lead to cellular apoptosis or necrosis (Figure 2)

But sometimes this GLP-1 system does not always work well

In a study published in 2012, researchers examined the weight loss effects of bupropion in patients struggling with obesity (1)

Clinical trials have demonstrated varying degrees of weight loss depending on the specific agent: liraglutide typically achieves 5-8% weight loss over 56 weeks (SCALE trials), while semaglutide has shown approximately 15% weight loss over 68 weeks (STEP trials)

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