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94 Cancer cells undergoing EMT may have greater sensitivity to ferroptosis, and cancer cells with mesenchymal characteristics are generally more vulnerable to ferroptosis than cancer cells with epithelial properties

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They create a platform for efficient calcium transfer and participate in signaling pathways that regulate cell viability ( In AP, activation of the IP 3 RSTIM1Orai1 pathway promotes prolonged elevation of cytosolic Ca 2+ , leading to mitochondrial calcium overload and injury ( 2+ -ATPase (SERCA) and PM Ca 2+ -ATPase (PMCA) calcium pumps, thus establishing a vicious cycle of ionic imbalance ( 2+ homeostasis ( 2+ overload appears to initiate mitochondrial damage, whereas ATP depletion further amplifies calcium dysregulation by compromising ATP-dependent Ca 2+ extrusion and reuptake mechanisms

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