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Cancer cells were sensitive to GGsTop when grown in cystine-free with GSH-supplemented conditions, but this increased sensitivity was reversed when cells were provided with cysteinylglycine, the product of GGT-mediated GSH catabolism (Fig

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Glutamine in cancer cells plays critical and diverse roles by providing not only a source of nitrogen for amino acid and nucleotide biosynthesis but also a source of carbon to replenish the tricarboxylic acid (TCA) cycle and lipid biosynthesis pathways

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