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Why does OROS Research perform testing beyond purity

Why did these patients fail standard treatment before

doi:10.1016/S0140-6736(21)01751-7 Dutta D, Nagendra L, Harish BG, et al

10.1038/s41419-024-06968-0 104

The primary outcome would be change in depressive symptom severity over 812 weeks using validated clinician-rated scales, with secondary outcomes including response and remission rates, anxiety, fatigue, cognitive function, sleep quality, and quality of life