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The mRNA transcripts of the GCLC subunit of glutamate cysteine ligase, which is the rate-limiting enzyme in GSH biosynthesis, as well as SLC7A11 which encodes the cystine/glutamate antiporter xCT, are previously unidentified targets for the RIDD activity of IRE1

Theres ongoing research in this area

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While supplementation with exogenous GSH has shown therapeutic potential on its own, recent findings indicate advantages to combined treatment with other immunomodulatory or anti-infective agents (Vairetti et al., 2021)

Pharmaceuticals (2023)