Side effect profile of combination therapy Combining two peptides does increase side effect burden
The niacinamide-containing tirzepatide formulations discussed earlier are partly motivated by this logic, since niacinamide is a NAD+ precursor
The absence of safety data in these populations means that use should be avoided or approached with extreme caution and specialized medical supervision
Within these populations are people with risk factors that might make them better candidates than others, such as: Stress: Chronic stress not only promotes an inflammatory state but also can prolong bacterial infections and discourage wound closure.7 21 22 Overweight or obesity: People with excess weight are also at risk for chronic inflammation, persistent infections, and slower wound healing
Dudek M, Angelucci C, Pathiranage D, Wang P, Mallikarjun V, Lawless C, et al