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With the advent of omics technologies it was soon recognized that GST enzymes are encoded by large gene families in plants (McGonigle et al., 2000

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Furthermore, these optimized molecules allow for less frequent administration, which places less burden on the patient and improved compliance

Commenters also noted that compiling and interpreting standard charge information is extraordinarily complex, requiring interpretation of numerous assumptions and formulas, changing regulatory requirements, and intricate contract terms, and expressed concern that there is no recognition that given the vastness of the data required, an error could be overlooked despite all efforts to prevent it