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( B ) chemical structure of tirzepatide showing the peptide sequence and the location of the C20 fatty-di-acid moiety

With no head-to-head trial, superiority claims in either direction are not evidence-based

Managing gastrointestinal side effects is also crucial to avoid dehydration-related complications, which could exacerbate kidney issues

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The aims of this review are (1) to provide an overview of the clinical and biological overlap between neuropsychiatric long COVID and other fatigue-associated neuropsychiatric disorders, (2) to examine the shared molecular mechanisms of fatigue and depressive symptoms involving acetylcarnitine metabolism, and finally (3) to review the current evidence on acetylcarnitine supplementation studies as a treatment for fatigue-associated syndromes and pharmacological aspects of acetylcarnitine supplementation to provide a conceptual foundation for acetylcarnitine supplementation in neuropsychiatric long COVID syndrome