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Clinical trials have shown that many patients experience gastrointestinal issues, including diarrhea, especially during the initial weeks of treatment

Theoretical concerns include subtle changes in gallbladder motility, pancreatic enzyme secretion, and gastric emptying that might not manifest as obvious symptoms but could have cumulative effects over years

The finding is promising but more data are needed, Yammine said

Statistical significance was calculated by two-way ANOVA followed by Dunnetts multiple comparisons test with ZT14 Control set as the reference group in a