Our experiment carried out in ex-vivo organoids derived from intestinal crypts demonstrated that ROS induces cell death in wild type Apc-expressing but not in Apc-mutated ex-vivo organoids
The shed eventually reverses and is generally considered a sign the treatment is working
J Clin Endocrinol Metab 104(5):17351752 Jeurissen S, Vergauwen G, Van Deun J, Lapeire L, Depoorter V, Miinalainen I, Sormunen R, Van den Broecke R, Braems G, Cocquyt V (2017) The isolation of morphologically intact and biologically active extracellular vesicles from the secretome of cancer-associated adipose tissue
The use of sulphonylureas, glinides or thiazolidinediones to manage type 2 diabetes is associated with a typical weight gain of 25 kg [52], but a randomised controlled comparison of acarbose and glibenclamide as monotherapy in 96 patients with diabetes found no weight changes associated with acarbose therapy [32]
They also recruited 45 demographically matched healthy controls
