-arrestin is the receptor's janitor once recruited, it does three harmful things: 1
Vitamin C, a well-known antioxidant, enhances the sensitivity of cancer cells resistant to imatinib by disrupting the Nrf2/ARE complex, resulting in decreased expression of the catalytic subunit of glutamate-cysteine ligase and lower GSH levels (175)
doi:10.4149/BLL_2019_068 Bauer IE, Green C, Colpo GD, et al
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