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The estrogen-deficient state may disrupt this careful coordination of energy substrate uptake and utilization, impairing postprandial insulin-mediated suppression of adipose tissue lipolysis and leading to a chronic excess supply of circulating NEFA to the liver, eventually overwhelming its capacity for lipid removal to cause liver fat accumulation (86)

Nutritional deficiencies especially when patients lack proper dietary guidance can manifest as fatigue, hair loss and even reduced bone density

2002 Dec;56(6):295-301

This enhanced penetration could lead to better delivery of the active compound to deeper skin layers, potentially resulting in more pronounced effects in certain skincare applications

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