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Subsequently, trials like Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction (DAPA-HF) [10] and Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction (DELIVER) [13] for dapaglifozin, as well as the Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure (EMPEROR-Reduced) [14] the Empagliflozin in Heart Failure with a Preserved Ejection Fraction (EMPEROR-Preserved) [15] trials for empaglifozin, have demonstrated a reduction in CV events regardless of LV ejection fraction (EF) and the presence of DM2
Fourth, apart from alteration of cellular currents in atrial cardiomyocytes caused by ROS, UA appears to have direct electrophysiological effects that promote AF (,)
Polyurea dendrimer folate-targeted nanodelivery of L-buthionine sulfoximine as a tool to tackle ovarian cancer chemoresistance
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