14 Government and prominent non-profit health organizations, such as the American Cancer Society (ACS) and the World Cancer Research Fund/American Institute of Cancer Research (WCRF/AICR), have issued guidelines and recommendations for cancer prevention since the 1980s, with a focus on weight management, physical activity, diet, and alcohol consumption
Most effects are mild and primarily involve transient gastrointestinal discomfort
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However, human clinical trials demonstrating sustained tissue accumulation and functional antioxidant benefit remain sparse, making real-world efficacy difficult to quantify
Souza-Moreira TM, Navarrete C, Chen X, Zanelli CF, Valentini SR, Furlan M, Nielsen J, Krivoruchko A