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C1q binds to the Fc region of IgG1 and IgM that are complement-fixing antibodies attached to the viral proteins 65 followed by the interaction between the corresponding receptor and complement protein that increases viral adhesion leading to the formation of the virus, antibody, and complement complex 42,66

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Drug-eluting microspheres have been widely used in the treatment of hepatocellular carcinoma for the simultaneous effects of embolization of blood vessels supplying tumors and sustained release of chemotherapeutic agents (137)