Kahn says she would remain skeptical
This contrasts sharply with orthobiologic therapies like PRP and mesenchymal stem cell therapies, both of which have been evaluated in multiple randomized controlled trials and large observational studies
Thymosin Beta-4 is an actin-sequestering peptide that enhances cell migration and reduces inflammatory cytokine production via the CXCR4/SDF-1 and NF-B pathways
The apparent lack of such a relationship for some drugs does not weaken the basic hypothesis but points to the need to consider the time course of concentration at the actual site of pharmacologic effect (see below)
[DOI] [PMC free article] [PubMed] [Google Scholar] 34.Sikiric P., Seiwerth S., Brcic L., Sever M., Klicek R., Radic B., Drmic D., Ilic S., Kolenc D