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When the derivation described by Kitz and Wilson [44] for irreversible inactivation was applied to the experimental data, only at low inhibitor concentration, the secondary plot expressing k obs as a function of inhibitor concentration followed Equation 2: where K I represents the dissociation constant of the inhibitor, and k i is the first-order rate constant for irreversible inactivation

Cellular basis for paracrine regulation of ovarian follicle development

Roldan V, Marin F, Lip GYH, Blann AD

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