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NICE guidance including Technology Appraisal TA875 (semaglutide 2.4 mg for managing overweight and obesity), Clinical Guideline CG189 (Obesity: identification, assessment and management), and Public Health Guidance PH53 (Weight management: lifestyle services for overweight or obese adults) recommends a structured, tiered approach to weight management

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Oxidative stress refers to an imbalance between the production of reactive oxygen species (ROS) and the bodys ability to detoxify these harmful byproducts or repair the resulting damage (Baghcheghi et al

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