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[1] [3] Beyond glycemic control, these medications slow gastric emptying, which prolongs satiety and reduces appetite through central nervous system pathways

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Based on the initial data obtained 10-15 years ago regarding the neuroprotective effects of GLP-1RA in rodent models of stroke and neurological diseases, it has been suggested that these non-pancreatic effects may be beneficial for patients with T2DM and neurological comorbidities [5]

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Linsitinib is also in a Phase 2b trial for this ophthalmological indication [64]