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This bidirectional, stable axis connects the gut with the central nervous system

Preclinical research suggests it acts as a potent non-selective agonist at melanocortin receptors, specifically MC3R and MC4R in the hypothalamus

Following the importation of offline MS data into Compound Discoverer 3.3 (ThermoFisher Scientific), analysis using the BGI Metabolome Database (BMDB), mzCloud database, and ChemSpider online database was conducted to generate a comprehensive data matrix that included details, such as metabolite peak areas and identification results

It is used to increase collagen and elastin in the skin to make it tight and smooth

It was first FDA-approved in 2010 under the brand name Egrifta for HIV-associated lipodystrophy, a condition causing excess visceral fat accumulation