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Another breakthrough in obesity medication acceptance was the SELECT trial [7], the first cardiovascular outcome trial in persons with overweight and obesity with established cardiovascular disease (prior myocardial infarction, stroke or symptomatic peripheral artery disease) to show reduction in major adverse cardiovascular events (MACE) [7]

Inadequate weight loss response (less than 5% body weight reduction after 1216 weeks at therapeutic doses) should trigger reassessment of the treatment plan

* **Evaluate your finances:** After exploring insurance and savings programs, can you realistically afford the expected out-of-pocket cost long-term without significant financial strain