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For high-stakes cases (recent cardiovascular event, severe obstructive sleep apnea, advanced metabolic disease), referencing the specific clinical trial evidence supporting use in that population strengthens the submission

Every protocol starts with a consultation, uses 503A pharmacy sourcing, and includes provider monitoring throughout

Patients taking anticoagulants or with liver disease should have a lower threshold for emergency evaluation

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NICE guidance (NG69) recommends specific psychological therapies, including enhanced CBT (CBT-E), for eating disorders