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Research suggests that a substantial number of women develop marginal or subclinical biotin deficiency during normal pregnancy (see also Disease Prevention) (8, 12, 13)

Nausea, vomiting, diarrhea, constipation, bloating, reflux, and reduced appetite may occur, especially during dose changes

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217 All the enzymes but PGI in the glycolysis and the TCA cycle can be acetylated under the control of sirtuins